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The product retained optical and chemical properties of HP with significant improvement in water solubility [118]

Once denatured, the peptide loses its specific biological activity

PICO Summary CagriSema for Obesity (REDEFINE 1) Phase 3a RCT - obesity without diabetes - 68 weeks CagriSema produced 20.4% mean weight loss at 68 weeks versus 3.0% with placebo in adults with obesity without diabetes

Raghunandan M, Yeo JE, Walter R, Saito K, Harvey AJ, Ittershagen S, Lee E, Yang J, Hoatlin ME, Bielinsky AK, Hendrickson EA, Schrer O, Sobeck A (2020) Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery